Seminar/Hội nghị

Immobilization and orientation control of functional proteins on the surfaces of materials has been regarded as a key factor for enhancement of performance of protein-based materials in the fields of bio-production, diagnostics and clinical treatments. Especially, Sensitive and accurate biomolecular sensing utilizing antibody-immobilized solid support of the solid-sensing materials are highly expected in clinical diagnosis, pharmaceutical process monitoring and environmental analysis. Here, we propose and demonstrate development of materials-binding peptides for site-specific immobilization of recombinant antibody fragments, such as single-chain Fv antibodies and single-domain antibodies (VHH).